RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
mir-21b
RNA ID
RNA Type
miRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
qRT-PCR; Dual-luciferase reporter assay; etc.
Target
Col1a1; Col1a2; Col3a1; Col4a1; Col4a2; Col15a1; Itga11; Adam12; Adamts9; Nid1
Pathway
NA
PubMed ID
Title
MiR-29 is a major regulator of genes associated with pulmonary fibrosis
Year
2010
Function
"The expression of miR-29 family members significantly reduced in fibrotic lungs. MiR-29 is suppressed by transforming growth factor (TGF)-B1and many fibrosis-associated genes up-regulated by TGF-B1 are derepressed by miR-29 knockdown. Interestingly, a comparison of TGF-B1 and miR-29 targets revealed that miR-29 controls an additional subset of fibrosis-related genes, including laminins and integrins, independent of TGF-B1."